mRNA Cap-2'-O-Methyltransferase RNases and inhibitors Cat#ON-268/ON-268-G

Cat#ON-268/ON-268-G

[1] Manoharan

" Journal of Biological Chemistry 281

SAM is unstable at pH 7-8

mRNA Cap-2'-O-Methyltransferase RNases and inhibitors Cat#ON-268/ON-268-GProduct Information mRNA Cap 2' O Methyltransferase is a recombinant protein from Vaccinia virus. The enzyme can add a methyl group at the 2' O position of the first nucleotide adjacent to the Cap structure at the 5' end of the RNA. The enzyme utilizes SAM as a methyl donor to methylate capped RNA (Cap 0) resulting in a cap 1 structure. The Cap 1 structure has been reported to enhance mRNA translation efficiency and hence may help improve expression